The extremist settlers were guarded by the Israeli regime forces.
According to the Palestinian Ma’an news agency, large groups of Israeli settlers, approximately 385 in total, “raided the mosque” on Thursday.
The intruding settlers tried to perform rituals and attempted to attack the mosque guards.
The al-Aqsa Mosque compound is a flashpoint Islamic site, which is also holy to the Jews.
Under a 1967 deal between Israel and Jordan, the compound’s custodian, non-Muslim worship is prohibited at the site.
In defiance of the agreement, the regime in Tel Aviv regularly allows Israeli settlers and extremists to enter the site and carry out religious rituals -- often under armed guard.
In a similar move on Wednesday, nearly 300 settlers and extremists entered the compound by force, performing acts deemed provocative by Palestinians.
Muslim bodies in Jerusalem al-Quds condemned the incursions, saying they are meant to change al-Aqsa’s historical character.
In a war in 1967, Israel captured the West Bank and East Jerusalem al-Quds, where the Aqsa Mossque compound is located. Since then, Tel Aviv has continued to expand its illegal settlements there.